A Canadian study reveals the therapeutic potential of dandelion extract against colorectal cancer in vitro and in vivo.

Understand the news at your own pace: To make the content more accessible while maintaining technical depth, this news story has been presented in two formats:

• Simplified version: Ideal for those who are not in the field, but are curious about the subject.

• Technical version: Aimed at readers with prior knowledge or professional interest in the topic. Choose the reading that best suits you—or enjoy both! Researchers at the University of Windsor in Canada discovered that dandelion root extract was able to eliminate over 90% of colon cancer cells in the laboratory. The study indicated that the natural compound, called DRE, triggers the programmed death of these cells without affecting healthy cells.

The active compound, called taraxasterol, was identified as responsible for stopping tumor growth and activating processes that lead to the self-destruction of cancer cells.

In addition to the laboratory results, tests on animal models confirmed the plant's anticancer potential. However, it is important to remember: there are still no human trials proving its safety or effectiveness in real-life treatment.

Another challenge is the lack of investment, as natural compounds like DRE are not patentable, which reduces interest from the pharmaceutical industry.

Accessible language: (News produced with the help of AI) Researchers at the University of Windsor, Canada, conducted studies with Dandelion Root Extract (DRE) and observed that Taraxacum officinale root extract induces apoptosis in over 90% of colon cancer cells within 48 hours, preserving normal cells.

The mechanism of action is related to taraxasterol, a phytosterol with anti-inflammatory and antitumor properties, which modulates intracellular pathways, including caspase-8 activation, mitochondrial depolarization, and the generation of reactive oxygen species (ROS), ultimately leading to programmed cell death.

In animal models, oral administration of DRE resulted in a greater than 90% reduction in tumor growth, reinforcing its potential as a therapeutic agent with high selectivity and low toxicity.

However, the lack of clinical studies in humans and the limited commercial interest generated by the extract's non-patentability are significant obstacles to advancing this research toward practical therapeutic applications. Technical language: (News produced with the help of AI)

Sources: https://gtnoticias.com.br/2025/07/ciencia-investiga-raiz-de-dente-de-leao-elimina-ate-90-das-celulas-de-cancer-de-colon-em-48-horas-mas-so-em-laboratorio/ https://cerebrodigital.net/raiz-de-dente-de-leao-terapia-cancer https://diaadianordeste.com.br/noticia/raiz-de-dente-de-leao-cancer-de-colon https://www.infoverus.com.br/noticia/raiz-de-dente-de-leao-e-estudo

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