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Dental pulp of third molars: DPSCs as a promising source for cardiac and neuroreceptive regenerative medicine.

  • Writer: Dakila News
    Dakila News
  • 3 hours ago
  • 3 min read

Understand the news at your own pace: To make the content more accessible while maintaining technical depth, this news story has been presented in two formats:

  • Simplified version: Ideal for those who are not in the field but are curious about the subject.

  • Technical version: Aimed at readers with prior knowledge or professional interest in the subject. Choose the reading that best suits you — or enjoy both!

Did you know that the wisdom tooth that is usually removed and discarded may contain something very valuable? Inside it is the dental pulp, a tissue that houses stem cells called Dental Pulp Stem Cells (DPSCs), which have shown the ability to transform into other types of cells — neurons, cartilage, bone, and even heart muscle.


Research indicates that, for example, DPSCs can be collected from wisdom teeth with little discomfort, since they are usually removed for other reasons. Then, stored in stem cell banks, they could be used in the future for personalized and less invasive treatments — for heart disease, neurodegenerative diseases such as Parkinson's disease, or Alzheimer's disease.


Of course, this doesn't mean you can go to the dentist today to guarantee a miraculous "rescue." The technology is still under development, clinical trials and regulations need to advance. But looking at wisdom teeth as "disposable waste" and not as a potential resource means that millions of opportunities are wasted.


So, the next time you have your wisdom teeth extracted, ask your dentist: “What if this tooth could become a resource for my body in the future?” This small tooth might hide a great medical possibility. Accessible language: (News produced with AI)


Dental pulp stem cells (DPSCs) isolated from impacted third molars (wisdom teeth) have emerged as a promising resource for tissue regeneration therapies due to their accessibility, multipotent potential, and reduced ethical maturity compared to other stem cell sources.


Studies have demonstrated in vitro differentiation of these DPSCs into neuronal, osteogenic, chondrogenic, and myogenic lineages, with initial evidence of activity in cardiac failure models, where pulp extracts improved ejection fraction in rodents.


In the neurological context, DPSCs derive from the neural crest and express neurogenic markers, justifying their investigation for nerve tissue regeneration, such as in stroke models or neurodegenerative diseases (e.g., Parkinson's disease), where neuroprotection, neurogenesis promotion, and immune modulation have been observed.


Dental stem cell banks for extracted wisdom teeth offer an "autologous" route of obtaining cells and can reduce the risk of rejection or the need to search for a donor. Despite expectations, there are significant challenges: robust long-term clinical trials are still lacking, and the standardization of differentiation and safety protocols (risk of tumorigenesis, functional integration) requires further investigation.


Furthermore, the feasibility of harvesting, the quality of DPSCs in adult teeth with caries, formed roots, or late extraction, and the cost-benefit ratio for population storage remain under debate.


For clinical practice in regenerative cardiology or neurotherapy, the current stage positions DPSCs as "promising in the pre-clinical phase." The next step includes multicenter trials to demonstrate functional efficacy, as well as clear regulatory guidelines for their safe application, before they become routine in hospitals and cell banks.

Technical language: (News produced with AI)



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